| Acute Generalized Exanthematous Pustulosis > > PubMed articles by:Am J Pathol. 2002 December; 161(6): 2079í¢Â€Â“2086. PMCID: PMC1850901 © 2002, American Society for Investigative PathologyAcute Generalized Exanthematous Pustulosis Role of Cytotoxic T Cells in Pustule FormationSimone Schmid, * Petra C. Kuechler, * Markus Britschgi, * Urs C. Steiner, * Nikhil Yawalkar, *†Alain Limat, ‡ Kurt Baltensperger, § Lasse Braathen, †and Werner J. Pichler*From the Clinic of Rheumatology and Clinical Immunology/Allergology* and the Clinic of Dermatology, †Inselspital, Bern; the Department of Pharmacology, § University of Bern, Bern; and Modex Thérapeutiques, ‡ Lausanne, SwitzerlandAccepted August 21, 2002. This article has been other articles in PMC.AbstractExtensive formation of nonfollicular sterile pustules on erythematous background combined with fever and peripheral blood leukocytosis are the characteristics of acute generalized exanthematous pustulosis. This uncommon eruption most often is an allergic reaction because of drugs such as aminopenicillins and sulfonamides inter alia. We recently demonstrated the important role of drug-specific T cells in the pathogenesis of this disease, showing that they produce high amounts of the neutrophil-attracting chemokine interleukin-8 and therefore stand out as a special subgroup of T cells, differing from the usual Th1 and Th2 subsets. In this study we use immunohistochemist...
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